Bioorganic and Medicinal Chemistry Letters p. 275 - 280 (1997)
Update date:2022-08-04
Topics:
Dorsch, Dieter
Mederski, Werner W.K.R.
Osswald, Mathias
Devant, Ralf M.
Schmitges, Claus-Jochen
Christadler, Maria
Wilm, Claudia
Highly active endothelin receptor antagonists can be obtained by replacing the aryloxy group of L-749,329 by diversely substituted pyridazinone residues. The syntheses and structure-activity relationships of the new aryl-oxopyridazinyl-N-(4-arylsulfonyl)-acetamides 2 are reported. 2p with a simple dimethylpyridazinone moiety was one of the most potent compounds in vitro.
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