Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists

DOI: 10.1016/S0960-894X(96)00617-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 275 - 280 (1997)

Update date:2022-08-04

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Authors:

Dorsch, Dieter

Mederski, Werner W.K.R.

Osswald, Mathias

Devant, Ralf M.

Schmitges, Claus-Jochen

Christadler, Maria

Wilm, Claudia

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Article abstract of DOI:10.1016/S0960-894X(96)00617-8

Highly active endothelin receptor antagonists can be obtained by replacing the aryloxy group of L-749,329 by diversely substituted pyridazinone residues. The syntheses and structure-activity relationships of the new aryl-oxopyridazinyl-N-(4-arylsulfonyl)-acetamides 2 are reported. 2p with a simple dimethylpyridazinone moiety was one of the most potent compounds in vitro.

Full text of DOI:10.1016/S0960-894X(96)00617-8

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