Bioorganic and Medicinal Chemistry Letters p. 275 - 280 (1997)
Update date:2022-08-04
Topics:
Dorsch, Dieter
Mederski, Werner W.K.R.
Osswald, Mathias
Devant, Ralf M.
Schmitges, Claus-Jochen
Christadler, Maria
Wilm, Claudia
Highly active endothelin receptor antagonists can be obtained by replacing the aryloxy group of L-749,329 by diversely substituted pyridazinone residues. The syntheses and structure-activity relationships of the new aryl-oxopyridazinyl-N-(4-arylsulfonyl)-acetamides 2 are reported. 2p with a simple dimethylpyridazinone moiety was one of the most potent compounds in vitro.
View MoreNanjing Norris Pharm Technology Co., Ltd.
Contact:+86-13901585132
Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Contact:+86-511-88790000
Address:338 North Yushan Rd, Zhenjiang, Jiangsu 212016
Ji'an Hairui Natural Plant Co. Ltd.
Contact:0796-8105528
Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Doi:10.1002/anie.200503305
(2006)Doi:10.1021/jm960546p
(1997)Doi:10.1021/jo970005n
(1997)Doi:10.1016/S0040-4039(97)00176-7
(1997)Doi:10.1016/j.tet.2005.05.065
(2005)Doi:10.1246/bcsj.41.647
(1968)
