Synthesis of 2-aryltryptamines with palladium catalyzed cross-coupling of 2-bromotryptamines and arylboronic acids

Article abstract of DOI:10.1016/S0040-4039(97)00797-1

A versatile and high-yielding synthesis of 2-aryltryptamines employing palladium(0) catalyzed cross-coupling of 2-bromotryptamines and arylboronic acids was developed. The preparation of the intermediate 2-bromotryptamines with pyridine hydrobromide perbromide as the brominating agent, is also reported.