Bioorganic and Medicinal Chemistry Letters p. 3637 - 3642 (1998)
Update date:2022-08-02
Topics:
Salituro, Francesco G.
Baker, Christopher T.
Court, John J.
Deininger, David D.
Kim, Eunice E.
Li, Biquin
Novak, Perry M.
Rao, Bhisetti G.
Pazhanisamy
Porter, Margaret D.
Schairer, Wayne C.
Tung, Roger D.
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
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