Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities

DOI: 10.1016/S0960-894X(97)00338-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1945 - 1950 (1997)

Update date:2022-08-04

Topics:

Authors:

Kim, Oak K.

Ueda, Yasutsugu

Mansuri, Muzammil M.

Russell, John W.

Bidwell, Valerie W.

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Article abstract of DOI:10.1016/S0960-894X(97)00338-7

A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 ~ 2 μg/mL) against MRSA and excellent stability in human plasma.

Full text of DOI:10.1016/S0960-894X(97)00338-7

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