Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities

DOI: 10.1016/S0960-894X(97)00338-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1945 - 1950 (1997)

Update date:2022-08-04

Topics:

Authors:

Kim, Oak K.

Ueda, Yasutsugu

Mansuri, Muzammil M.

Russell, John W.

Bidwell, Valerie W.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00338-7

A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 ~ 2 μg/mL) against MRSA and excellent stability in human plasma.

Full text of DOI:10.1016/S0960-894X(97)00338-7

Products guided by the article

Product name:(6R,7R)-3-Chloromethyl-7-[2-(2,5-dichloro-phenylsulfanyl)-acetylamino]-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Cas No:195213-51-5

R&D Labs maybe for 195213-51-5

QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

website:http://www.zyterpharm.com

Contact:+86-18858184290

Address:West Wenyi Road, Cangqian, Yuhang
Suzhou Candor Chemical Technology Co.,Ltd.

Contact:+86 512 62626136

Address:A427, Guohua Building, No.328 Xinghu Road
zhejiang huangyan wanfeng pharm chem co.ltd

Contact:+86-576- 84160728

Address:No. 5 Dazha Road, Economic,Development Zone(JiangKou), Zhejiang, China
Yueyang Hudex Pharmaceuticals Ltd.

Contact:0730-8748800

Address:Wujiang Bridge，Yueyang Economy & Technology Development Zone

Relevant to this article

Synthesis and Reactions of 1,2-Cyclopropanated Sugars

Doi:10.1021/jo970948k
(1997)
Chromium(III)-salen complex nanoparticles on AlPO₄: as an efficient heterogeneous and reusable nanocatalyst for mild synthesis of highly functionalized piperidines, 2-arylbenzimidazoles, and 2-arylbenzothiazoles

Doi:10.1007/s13738-017-1097-x
(2017)
A new and rapid access to a 14-membered diketal dilactam ring

Doi:10.1016/S0040-4039(97)01282-3
(1997)
New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization

Doi:10.1246/cl.1997.935
(1997)
Self-assembly of a series of metal–organic frameworks with semi-rigid multicarboxylate 3,4-bis(carboxymethoxy)benzoic acid ligands

Doi:10.1016/j.poly.2017.06.039
(2017)
Chloride labilization resulting from nucleophilic addition to cis-Ru(tpy)(CO)₂Cl⁺PF₆^-: Synthesis and characterization of new CO₂-bridged and formate complexes of ruthenium

Doi:10.1021/om970493p
(1997)

Article Doi