Stereocontrolled synthesis of the key intermediate for the enantioselective synthesis of clerodane natural products

Article abstract of DOI:10.1016/S0040-4039(97)01614-6

Stereocontrolled synthesis of (+)-trans-decalone 7 (R = CH=CH₂) from (-)-verbenone (5), readily obtainable from (+)-nopinone (2), is described. The compound 7 possesses four correctly arranged chiral centers, C(5)-C(10)-C(9)-C(8), necessary for the enantioselective synthesis of neo-trans-clerodanes.