Bioorganic and Medicinal Chemistry Letters p. 2523 - 2526 (1997)
Update date:2022-08-03
Topics:
Tsuruta, Osamu
Shinohara, Go
Yuasa, Hideya
Hashimoto, Hironobu
Uridine 5'-(N-acetyl-5-thio-galactosaminyl diphosphate) (UDP-5SGalNAc) was synthesized from an N-acetylgalactosamine derivative via ring opening-recyclization approach. UDP-5SGalNAc was active as a donor substrate for lactose synthase, the complex of galactosyltransferase and lactalbumin, giving the disaccharide mimic (5SGalNAcβ[1→4]GlcNAc) which has a sulfur in the ring of the non-reducing sugar. The initial rate of the formation of the disaccharide mimic was 0.23% that for the natural disaccharide (GalNAcβ[1→4]GlcNAc).
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