
Tetrahedron p. 16327 - 16340 (1997)
Update date:2022-08-04
Topics:
Comins, Daniel L.
Thakker, Paresh M.
Baevsky, Matthew F.
Badawi, Mohamed M.
Cyclohexyl-based chiral auxiliaries can be used effectively in an asymmetric Pictet-Spengler synthesis of tetrahydroisoquinoline, aporphine and protoberbine alkaloids. Using this strategy, concise asymmetric syntheses of (-)-laudanosine, (+)-glaucine and (+)- xylopinine have been accomplished.
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