Synthesis of key sandramycin analogs: Systematic examination of the intercalation chromophore

Article abstract of DOI:10.1016/S0968-0896(97)10014-1

The preparation and examination of 2-22 constituting a systematic study of the chromophore of sandramycin (1) are detailed. Fluorescence quenching studies were used to establish binding constants for 1-24 within calf thymus DNA, within a single high affin