Biological and pharmaceutical bulletin p. 1387 - 1390 (2000)
Update date:2022-07-29
Topics:
Takahashi
Ishioka
Koiso
Sodeoka
Hashimoto
Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxicity. However, some compounds, including 4,4'-dinitroazobenzene (25), 4,4'-dimethoxyazobenzene (33), and 2,2'-dichloroazoxybenzene (47), possessed potent anti-androgenic activity without apparent cell toxicity.
View MoreYueyang Hudex Pharmaceuticals Ltd.
Contact:0730-8748800
Address:Wujiang Bridge，Yueyang Economy & Technology Development Zone
Nantong Auxin Electronic Technology Co., LTD
Contact:86-513-88760026
Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Ningxia Soochow Agrochemical Limited Company
Contact:(+86）0512 6320 8190
Address:wujiang
Contact:+86 021-51698675
Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China
Huangshan Honghui Pharm Technology Co., Ltd.(expird)
website:http://www.honghuichem.com
Contact:18855958372
Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
Doi:10.1039/a800035b
(1998)Doi:10.1039/a801939h
(1998)Doi:10.1016/S0223-5234(98)80013-5
(1998)Doi:10.1080/15257770.2019.1675169
(2020)Doi:10.1016/S0040-4020(98)00950-8
(1998)Doi:10.1016/S0040-4039(98)00759-X
(1998)
