Solid phase synthesis of a 1,3,5-trisubstituted pyridinium salt library

Article abstract of DOI:10.1016/S0040-4039(98)00683-2

The synthesis of a 1,3,5-trisubstituted pyridinium salt combinatorial array containing two variable groups was accomplished in good yields. This entailed the incorporation of 5-bromonicotinic acid onto the resin, followed by Pd(0) catalyzed Suzuki coupling, then alkylation of the pyridine nitrogen and finally cleavage from the resin. A mix and split scheme was also carried out.