Tetrahedron Letters p. 3885 - 3888 (1998)
Update date:2022-08-03
Topics:
Lago, M. Amparo
Nguyen, Thomas T.
Bhatnagar, Pradip
The synthesis of a 1,3,5-trisubstituted pyridinium salt combinatorial array containing two variable groups was accomplished in good yields. This entailed the incorporation of 5-bromonicotinic acid onto the resin, followed by Pd(0) catalyzed Suzuki coupling, then alkylation of the pyridine nitrogen and finally cleavage from the resin. A mix and split scheme was also carried out.
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