Conformationally constrained no synthase inhibitors: Rigid analogs of L- N-iminoethylornithine

DOI: 10.1016/S0960-894X(98)00532-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2961 - 2966 (1998)

Update date:2022-09-26

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Authors:

Eustache, Jacques

Grob, Alfred

Lam, Charles

Sellier, Odile

Schulz, Gerhard

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Article abstract of DOI:10.1016/S0960-894X(98)00532-0

The synthesis of eight rigid analogs of L-N-iminoethylomithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.

Full text of DOI:10.1016/S0960-894X(98)00532-0

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