Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate

DOI: 10.1016/S0960-894X(98)00709-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 123 - 126 (1999)

Update date:2022-07-30

Topics:

Authors:

Wityak, John

Tobin, A. Ewa

Mousa, Shaker A.

Wexler, Ruth R.

Olson, Richard E.

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Article abstract of DOI:10.1016/S0960-894X(98)00709-4

Isoxazolinylacetamides bearing a phosphoramidate group α- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.

Full text of DOI:10.1016/S0960-894X(98)00709-4

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