Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate

DOI: 10.1016/S0960-894X(98)00709-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 123 - 126 (1999)

Update date:2022-07-30

Topics:

Authors:

Wityak, John

Tobin, A. Ewa

Mousa, Shaker A.

Wexler, Ruth R.

Olson, Richard E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00709-4

Isoxazolinylacetamides bearing a phosphoramidate group α- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.

Full text of DOI:10.1016/S0960-894X(98)00709-4

Products guided by the article

Product name:(S)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-2-(diethoxy-phosphorylamino)-propionic acid methyl ester

Cas No:221341-01-1

R&D Labs maybe for 221341-01-1

Yurui(Shanghai)Chemical Co.,Ltd

Contact:0086 21-50456736

Address:No.3188 Xiupu Road,Shanghai
Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd

Contact:+86-791-86899381

Address:Nanchang, Jiangxi, China
Shijiazhuang Yunxuan Im&Export Co.,Ltd.

Contact:+86-311-83037514

Address:No.6 Hongbin Road
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China

Relevant to this article

Synthesis of 6-N-biotinylaminohexyl isopropyl phosphorofluoridate: A potent tool for the inhibition/isolation of serine esterases and proteases

Doi:10.1055/s-1999-3419
(1999)
Direction of cyclization of 1,2-bis-(cyanomethyl)benzenes.

Doi:10.1021/jo00827a064
(1970)
Synthesis of the two monomethyl esters of the disaccharide 4-O-α-D-galacturonosyl-D-galacturonic acid and of precursors for the preparation of higher oligomers methyl uronated in definite sequences

Doi:10.1016/S0008-6215(98)00312-7
(1998)
Characteristic detection and determination of aliphatic aldehydes

Doi:10.1248/cpb.23.891
(1975)
Doi:10.1021/ja01116a041
(1953)
New modified nucleoside 5′-triphosphates: Synthesis, properties towards DNA polymerases, stability in blood serum and antiviral activity

Doi:10.1039/a900336c
(1999)

Article Doi