Bioorganic and Medicinal Chemistry Letters p. 123 - 126 (1999)
Update date:2022-07-30
Topics:
Wityak, John
Tobin, A. Ewa
Mousa, Shaker A.
Wexler, Ruth R.
Olson, Richard E.
Isoxazolinylacetamides bearing a phosphoramidate group α- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.
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