Bioorganic and Medicinal Chemistry Letters p. 341 - 346 (1999)
Update date:2022-07-29
Topics:
Adediran
Cabaret
Pratt
Wakselman
The cyclic depsipeptide 8-carboxy-3-phenylacetamido-3,4-dihydro-2H-1- benzopyran-2-one, a cyclic analog of aryl phenaceturates with structural similarity to cephalosporins, has been synthesized as a potential substrate/inhibitor of β-lactam-recognizing enzymes. It was found to be a tight-binding, poor substrate of class A β-lactamases and an irreversible inhibitor of several DD-peptidases.
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