A 'cephalosporin-like' cyclic depsipeptide: Synthesis and reaction with β-lactam-recognizing enzymes

DOI: 10.1016/S0960-894X(98)00739-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 341 - 346 (1999)

Update date:2022-07-29

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Authors:

Adediran

Cabaret Cabaret

Pratt Pratt

Wakselman

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Article abstract of DOI:10.1016/S0960-894X(98)00739-2

The cyclic depsipeptide 8-carboxy-3-phenylacetamido-3,4-dihydro-2H-1- benzopyran-2-one, a cyclic analog of aryl phenaceturates with structural similarity to cephalosporins, has been synthesized as a potential substrate/inhibitor of β-lactam-recognizing enzymes. It was found to be a tight-binding, poor substrate of class A β-lactamases and an irreversible inhibitor of several DD-peptidases.

Full text of DOI:10.1016/S0960-894X(98)00739-2

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