Journal of labelled compounds and radiopharmaceuticals p. 29 - 41 (1999)
Update date:2022-08-05
Topics:
Moenius
Voges
Mahnke
Burtscher
Metz
Guenat
An optimized fermentation process is described for the carbon-14 labelling of rapamycin. It is characterized by good reproducibility, high radiochemical purity and excellent yields. L-[14C2]Pipecolic acid and (1R,3R,4R)-3,4-dihydroxy[1,7-14C2]cyclohexane carboxylic acid ([14C2]DHCCA) synthesized in an effective stereoselective approach proved to be highly suitable precursors for this purpose. In a final step [14C4]rapamycin was converted by selective 14C(40)-O-alkylation to [14C4]NVP RAD001, a highly interesting immunosuppressant.
View MoreContact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Hebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Shandong Yuanli Science and Technology Co., Ltd.
Contact:86-0536-6777557
Address:Zhuliu Industiral Park,Changle County
website:http://www.NEM.COM.CN
Contact:+86-393-4411771
Address:The west section of shengli Road,Puyang,Henan Province,China
Doi:10.1016/j.cplett.2006.01.003
(2006)Doi:10.1016/S0960-894X(98)00742-2
(1999)Doi:10.1021/acscatal.6b02541
(2016)Doi:10.1021/jo9823339
(1999)Doi:10.1007/BF01374028
(1996)Doi:10.1007/BF02311337
(1998)