Highly enantioselective synthesis of 3-hydroxy-2-phenylpiperidine via the sharpless AD-reaction

DOI: 10.3987/COM-99-8489

Source and publish data:

Heterocycles p. 1067 - 1071 (1999)

Update date:2022-07-29

Topics:

Authors:

Stadler, Heinz

Boes, Michael

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Article abstract of DOI:10.3987/COM-99-8489

Asymmetric dihydroxylation (AD) of the silyl enol ether (3) provided after hydrolysis the hydroxy ketone (4). Subsequent hydrogenation yielded the title compound (1) as a diastereomeric mixture. The cis-isomer is an important building block for the synthe

Full text of DOI:10.3987/COM-99-8489

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Product name:(Z)-(5-azido-1-phenylpent-1-enyloxy)(tert-butyldimethyl)silane

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