Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease

DOI: 10.1016/j.ejmech.2018.12.013

Source and publish data:

European Journal of Medicinal Chemistry p. 512 - 526 (2019)

Update date:2022-08-15

Topics:

Authors:

Hu, Jinhui

Pan, Tingting

An, Baijiao

Li, Zhengcunxiao

Li, Xingshu

Huang, Ling

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Article abstract of DOI:10.1016/j.ejmech.2018.12.013

Considering the importance of PDE4D inhibition and the modulation of biometals in Alzheimer's disease (AD) therapeutics, we have designed, synthesized and evaluated a series of new clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands fo

Full text of DOI:10.1016/j.ejmech.2018.12.013

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Product name:8-(benzyloxy)-5,7-dichloro-2-methylquinoline

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