Structure-based design of a non-peptidic antagonist of the SH2 domain of Grb2

DOI: 10.1016/S0960-894X(99)00299-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1973 - 1978 (1999)

Update date:2022-08-04

Topics:

Authors:

Caravatti, Giorgio

Rahuel, Joseph

Brigitte, Gay

Furet, Pascal

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00299-1

The structure-based design and synthesis of a completely non-peptidic, micromolar antagonist of the SH2 domain of Grb2 is presented. The compound mimics the two main pharmacophores of the natural ligand, the phenylphosphate of the phosphotyrosine residue and the β-carboxamide of the X₊₂ asparagine, which are linked by a rigid aromatic spacer.

Full text of DOI:10.1016/S0960-894X(99)00299-1

Products guided by the article

Product name:4-AMinopyriMidine-2-carbothioaMide

Cas No:245321-47-5

R&D Labs maybe for 245321-47-5

Xiamen Huasing Chemicals Co.Ltd.

Contact:0086-592-6228397

Address:NO.24, Xinglin North 2nd Road,Jimei district
Jiangsu Zenji Pharmaceuticals LTD

Contact:+86-025-83172562; +1-224-888-1133(USA)

Address:No.5 Xinmofan Road
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Hefei Highzone Fine Chemical S&T CO.,LTD

Contact:86-0551-63663560

Address:room 1801 NO. 24 Shuguang RD.
Maithili Life Sciences

Contact:+91 9963263336

Address:Plot#146A, IDA Mallapur, Hyderabad - 500072

Relevant to this article

Mononuclear half-sandwich rhodium complexes containing phenylchalcogenolato ligands: A multinuclear (¹H, ¹³C, ³¹P, ⁷⁷Se, ¹⁰³Rh, ¹²⁵Te) magnetic resonance study

Doi:10.1016/S0022-328X(99)00216-8
(1999)
Fleming-Tamao oxidation and masked hydroxyl functionality: Total synthesis of (+)-pramanicin and structural elucidation of the antifungal natural product (-)-pramanicin

Doi:10.1021/jo9905672
(1999)
Synthesis of a conformationally locked AZT analogue, 3'-azido-3'-deoxy- 2'-O,4'-C-methylene-5-methyluridine

Doi:10.1016/S0040-4039(99)01324-6
(1999)
Templating Porphyrin Anisotropy via Magnetically Aligned Carbon Nanotubes

Doi:10.1002/cplu.201800623
(2019)
Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

Doi:10.1021/jm058160e
(2005)
Convenient and solventless preparation of pure carbon nanotube/ polybenzoxazine nanocomposites with low percolation threshold and improved thermal and fire properties

Doi:10.1039/c4ta00217b
(2014)

Article Doi