Synthesis of δ-amino acids with an ether linkage in the main chain and nucleobases on the side chain as monomer units for oxy-peptide nucleic acids

Article abstract of DOI:10.1016/S0040-4020(99)00541-4

Syntheses of four N-Fmoc δ-amino acids with an ether linkage in the main chain and four different nucleobases on the side chain, Fmoc-NH- C*H(CH₂-CH₂-B)-CH₂-O-CH₂-COOH (B=thymine, uracil, N⁴-benzoylcytosine, and N²-isobutyrylguanine) are described. The δ-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs).