Journal of Heterocyclic Chemistry p. 1123 - 1127 (1999)
Update date:2022-07-30
Topics:
Ferrarini, Pier Luigi
Mori, Claudio
Manera, Clementina
Mori, Filippo
Calderone, Vincenzo
Martinotti, Enrica
We report the condensation of substituted 2-aminopyridines 5 with β- ketocarboxylic esters in polyphosphoric acid. In this reaction were obtained together with the target compounds, 4H-pyrido[1,2-a]pyrimidin-4-ones 6 also the pyridin-2-ones 7. All the compounds 7 were tested for their calcium- antagonistic activity but failed to evoke any vasorelaxant response.
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