Synthesis of dimer phosphoramidite synthons for oligodeoxyribonucleotide phosphorothioates using diethyldithiocarbonate disulfide as an efficient sulfurizing reagent

Article abstract of DOI:10.1080/07328319908044844

An efficient solution phase synthesis of deoxyribonucleoside phosphorothioate dimers utilizing phosphoramidite approach is described. Diethyldithiocarbonate disulfide (DDD) was found to be an efficient sulfurizing reagent in the conversion of phosphite triesters to phosphorothioate triesters.

Full text of DOI:10.1080/07328319908044844

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Synthesis of Dimer Phosphoramidite
Synthons for Oligodeoxyribonucleotide
Phosphorothioates Using
Diethyldithiocarbonate disulfide as an
Efficient Sulfurizing Reagent
Alessandra Eleuteri a , Zacharia S. Cheruvallath a , Daniel C. Capaldi
a , Douglas L. Cole Vasulinga a & T. Ravikumar a
a Isis Pharmaceuticals , 2292 Faraday Avenue, Carlsbad, CA, 92008
Published online: 04 Oct 2006.
To cite this article: Alessandra Eleuteri , Zacharia S. Cheruvallath , Daniel C. Capaldi , Douglas
L. Cole Vasulinga & T. Ravikumar (1999) Synthesis of Dimer Phosphoramidite Synthons for
Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate disulfide as an Efficient
Sulfurizing Reagent, Nucleosides and Nucleotides, 18:8, 1803-1807, DOI: 10.1080/07328319908044844
To link to this article: http://dx.doi.org/10.1080/07328319908044844
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