Synthesis of some 5-furfuryl pyrido[2,3-d] pyrimidines and 1-ethyl-5-furfuryl pyrido[2,3-d] pyrimidines as possible antitumor & anticancer agents

Article abstract of DOI:10.1080/10426509808032456

Synthesis of some novel 5-furfuryl pyrido[2,3-d]pyrimidines was carried out by the condensation of 2-amino-3-cyano-4-furfuryl-6-substituted pyridine with various arylisothiocyanates, thiourea and carbondisulphide. These compounds on treatment with ethylbromide using phase transfer catalyst gave 1-ethyl-5-furfuryl pyrido[2,3-d]pyrimidines. The structure of the compounds has been established by elemental, IR and NMR studies. The compounds thus synthesized were screened for their antimicrobial activity.

Full text of DOI:10.1080/10426509808032456

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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SYNTHESIS OF SOME 5-FURFURYL
PYRIDO[2,3-d] PYRIMIDINES AND 1-
ETHYL-5-FURFURYL PYRIDO[2,3-d]
PYRIMIDINES AS POSSIBLE ANTITUMOR &
ANTICANCER AGENTS
Gajendra Singh a , Anoop K. Sharma a , A. K. Mishra a & L. Prakash a
a Department of Chemistry , University of Rajasthan , Jaipur, 302004,
India
Published online: 24 Sep 2006.
To cite this article: Gajendra Singh , Anoop K. Sharma , A. K. Mishra & L. Prakash (1998) SYNTHESIS OF
SOME 5-FURFURYL PYRIDO[2,3-d] PYRIMIDINES AND 1-ETHYL-5-FURFURYL PYRIDO[2,3-d] PYRIMIDINES AS
POSSIBLE ANTITUMOR & ANTICANCER AGENTS, Phosphorus, Sulfur, and Silicon and the Related Elements,
133:1, 83-93, DOI: 10.1080/10426509808032456
To link to this article: http://dx.doi.org/10.1080/10426509808032456
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