Journal of Organic Chemistry p. 3986 - 3989 (1980)
Update date:2022-07-30
Topics:
Swaringen, Roy A.
Eaddy, John F.
Henderson, Thomas R.
The scope of the reaction of ortho esters with secondary amines has been explored.With p-toluenesulfonic acid as catalyst, N-alkylanilines and orthoformates gave high yields of N-alkylformanilides and N,N-dialkylanilines in contrast to previous work with other acid catalysts where ortho amides were produced in low yield.Aliphatic cyclic amines (e.g., morpholine, piperidine) and orthoformates gave the corresponding ortho amides.This constitutes a new convenient synthesis of these useful reagents.
View MoreContact:86-371-86169316
Address:No.1,Shakou Road,Zhengzhou,China
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Arshine Pharmaceutical Co., Limited
website:http://www.cnarshine.com
Contact:0731-88503671
Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Yangzhou Zhongbao Pharmaceutical Co.,Ltd
Contact:+86-514-88290838
Address:Jiangsu Baoying county economic develpment zone in baoying avenue91
Huangshi Shennong Chemical Technology Co., Ltd
Contact:+86-714-3072290
Address:Eastern industrial park , Tieshan district , Huangshi city ,Hubei province , China
Doi:10.1021/jm00293a029
(1971)Doi:10.1016/j.tet.2021.131929
(2021)Doi:10.1021/ic50107a002
(1972)Doi:10.1021/jm00293a011
(1971)Doi:10.1021/jo00021a027
(1991)Doi:10.1007/BF00471322
()
