Journal of Organic Chemistry p. 3986 - 3989 (1980)
Update date:2022-07-30
Topics:
Swaringen, Roy A.
Eaddy, John F.
Henderson, Thomas R.
The scope of the reaction of ortho esters with secondary amines has been explored.With p-toluenesulfonic acid as catalyst, N-alkylanilines and orthoformates gave high yields of N-alkylformanilides and N,N-dialkylanilines in contrast to previous work with other acid catalysts where ortho amides were produced in low yield.Aliphatic cyclic amines (e.g., morpholine, piperidine) and orthoformates gave the corresponding ortho amides.This constitutes a new convenient synthesis of these useful reagents.
View Morewebsite:http://www.konochem.com
Contact:86-29-86107037
Address:No.170 West Avenue,Xi’an 710082,China
Beijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD
Contact:+86-755-82412922
Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
Xi'an HO-SHINE Bio-Technology Co., Ltd
Contact:+86 (29) 8248-5435/18292020086
Address:No.6 Shiyuan Road Xian City Shaanxi Province, 710048 China
website:http://www.sigmaaldrich.com
Contact:800 558-9160
Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Doi:10.1021/jm00293a029
(1971)Doi:10.1016/j.tet.2021.131929
(2021)Doi:10.1021/ic50107a002
(1972)Doi:10.1021/jm00293a011
(1971)Doi:10.1021/jo00021a027
(1991)Doi:10.1007/BF00471322
()
