Regioselective Enzymatic Deacetylation of Sucrose Octaacetate in Organic Solvents.

Article abstract of DOI:10.1016/0040-4039(94)88316-5

The first examples of deacetylation of sucrose octaacetate using proteases and lipases in organic solvents are reported.The regiochemistry of the product sucrose hepta-, hexa- and pentaacetates was established by perdeuteroacetylation and 1H-NMR.Preparation of key intermediates in the commerical synthesis of the high intensity sweetener, sucralose was achieved.