ANNOQUINONE-A, AN ANTIMICROBIAL AND CYTOTOXIC PRINCIPLE FROM ANNONA MONTANA

Article abstract of DOI:10.1016/S0031-9422(00)82257-8

A new naturally occuring phenanthrene-1,4-quinone, annoquinone-A, along with parietin (physcion) and β-sitostenone were isolated from the stem bark of Annona montana.The structure of annoquinone-A was elucidated by spectral methods and synthesis.Annoquinone-A demonstrated potent antimicrobial activity against Bacillus subtilis and Micrococcus luteus as well as cytotoxicity in the KB (ED50=0.16 μg/ml) tissue culture assay. β-Sitostenone also showed significant cytotoxicity.Key Word Index - Annona montana; Annonaceae; phenanthrene-1,4-quinone; annoquinone-A; anthraquinone; antibacterial activity; cytotoxicity.