Synthesis and structure activity relationships of 5-substituted-4′-thio-β-D-arabinofuranosylcytosines

Article abstract of DOI:10.1080/15257770008045474

Four 5-substituted (chloro, fluoro, bromo, methyl) 1-(4-thio-β-D-arabinofuranosyl) cytosines and their α anomers were synthesized by a facile route in high yields. All of these nucleosides were evaluated for cytotoxicity against a panel of human tumor cell lines in vitro. Only 5-fluoro-1-(4-thio-β-D-arabinofuranosyl)cytosine was found to be highly cytotoxic in all the cell lines and was further evaluated in vivo.

Full text of DOI:10.1080/15257770008045474

Nucleosides, Nucleotides and Nucleic Acids
ISSN: 1525-7770 (Print) 1532-2335 (Online) Journal homepage: http://www.tandfonline.com/loi/lncn20
Synthesis and Structure Activity
Relationships of 5-Substituted - 4′-thio-β-D-
Arabinofuranosylcytosines
Kamal N. Tiwari , Anita T. Shortnacy-fowler , Loredana Cappellacci , William
R. Waud , William B. Parker , John A. Montgomery & John A. Secrist III
To cite this article: Kamal N. Tiwari , Anita T. Shortnacy-fowler , Loredana Cappellacci ,
William R. Waud , William B. Parker , John A. Montgomery & John A. Secrist III
(2000) Synthesis and Structure Activity Relationships of 5-Substituted - 4′-thio-β-D-
Arabinofuranosylcytosines, Nucleosides, Nucleotides and Nucleic Acids, 19:10-12, 2005-2017,
DOI: 10.1080/15257770008045474
To link to this article: http://dx.doi.org/10.1080/15257770008045474
Published online: 17 Apr 2008.
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Date: 05 November 2015, At: 20:10