Synthesis of L-[4,5,5,5-D4]isoleucine: Determination of approximate rotamer population about the Cβ-Cγ bond

Article abstract of DOI:10.1002/jlcr.439

An asymmetric synthesis of regio- and stereoselectively deuteriumlabelled L-isoleucine was examined. An unsaturated γ-lactam readily available from L-pyroglutamic acid was stereoselectively methylated by the Gilman reagent and subsequent oxidation of the