Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydo-β-carboline derivatives

DOI: 10.1248/cpb.43.783

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 783 - 787 (1995)

Update date:2022-08-02

Topics:

Authors:

Kawashima

Horiguchi

Taguchi Taguchi

Tuyuki Tuyuki

Karasawa

Araki Araki

Hatayama

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Article abstract of DOI:10.1248/cpb.43.783

A series of 1,2,3,4-tetrahydro-β-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-β-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.

Full text of DOI:10.1248/cpb.43.783

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