Ruthenium-catalyzed synthesis of substituted 2-hydroxymorpholines and substituted morpholines

Article abstract of DOI:10.1016/S0040-4039(00)91563-6

The reaction of primary amines with peroxides afforded substituted hydroxymorpholines which were then converted to substituted morpholines via dihydrooxazines as intermediates. The reaction appears to proceed through a ruthenium-catalyzed dehydrogenation-cyclization process.