Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching

DOI: 10.1021/ja210088v

Source and publish data:

Journal of the American Chemical Society p. 4731 - 4742 (2012)

Update date:2022-08-04

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Authors:

Parkesh, Raman

Childs-Disney, Jessica L.

Nakamori, Masayuki

Kumar, Amit

Wang, Eric

Wang, Thomas

Hoskins, Jason

Tran, Tuan

Housman, David

Thornton, Charles A.

Disney, Matthew D.

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Article abstract of DOI:10.1021/ja210088v

Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3'-untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The transcribed repeats fold into an RNA hairpin with multiple copies of a

Full text of DOI:10.1021/ja210088v

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