Bioorganic and Medicinal Chemistry Letters p. 1451 - 1456 (2002)
Update date:2022-08-03
Topics:
Alexander
Warrellow
Eaton
Boyd
Head
Porter
Brown
Reuberson
Hutchinson
Turner
Boyce
Barnes
Mason
Cannell
Taylor
Zomaya
Millican
Leonard
Morphy
Wales
Perry
Allen
Gozzard
Hughes
Higgs
The discovery, synthesis and biological activity of a series of triarylethane phosphodiesterase 4 inhibitors is described. Structure-activity relationship studies are presented for CDP840 (29), a potent, chiral, selective inhibitor of PDE 4 (IC50 View More
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