Solid phase synthesis of substituted aminosulfonyl ureas using a sulfonylcarbamate linker

Article abstract of DOI:10.1016/S0040-4039(97)01795-4

A procedure for preparing substituted aminosulfonyl ureas on solid support is described. Chemoselective reaction of chlorosulfonyl isocyanate with the Wang resin followed by reaction with an amine provides resin-bound substituted aminosulfonylcarbamates. Heating of the resultant resin in THF with a second amine provides the desired substituted aminosulfonyl ureas in good yield and purity.