Synthesis of eupomatenoids by three consecutive transition metal-catalyzed cross-coupling reactions

Article abstract of DOI:10.1016/S0040-4039(02)02287-6

Six different eupomatenoids (1a-c, 1f-h) were prepared from 2,3,5-tribromobenzofuran (2) in a concise and high-yielding synthetic sequence. The overall yields vary between 29 and 60% over four to six steps. Key to the success of the syntheses is the high