Tetrahedron Letters p. 9213 - 9216 (2002)
Update date:2022-07-30
Topics: Ligands Tubulin Design and Synthesis Epothilones Preliminary Study
Vielle, Sophie
Raimbaud, Eric
Bertrand, Philippe
Quintard, Delphine
Renard, Pierre
Pfeiffer, Bruno
Gesson, Jean-Pierre
Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1,3-dione.
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