Synthesis, antitumor activity of 2-amino-4H-benzo[h]chromene derivatives, and structure-activity relationships of the 3- and 4-positions

Article abstract of DOI:10.1007/s00044-013-0602-8

Several 2-amino-4H-benzo[h]chromenes (3a-i) and (5a-h) were obtained by reaction of 4-chloro-1-naphthol (1) with α-cyanocinnamonitrile (2a-i) or ethyl α-cyanocinnamate derivatives (4a-h), respectively. Structures of these compounds were established on the