BIOTRANSFORMATION OF 18Β-GLYCERRHETINIC ACID BY CELL SUSPENSION CULTURES OF GLYCYRRHIZA GLABRA

Article abstract of DOI:10.1016/0031-9422(90)83026-W

Two biotransformation products formed from 18β-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra were isolated and their strucutres determined by chemical and spectral data as 3-O-<α-L-aranibopyranosyl-(1->2)-β-D-Glucuronopyranosyl>-24-hydroxy-18β-glycyrrhetinic acid and 30-O-β-D-glycopyranosyl-18β-glyrrhetinic acid.The formation of glycyrrhizin, the main triterpene glucuronide of the licorice root, was not detected among the biotransformation products.This is the first report of the glucuronylation of an exogenous triterpene in plant cell cultures.