Cytotoxicity and suppression of immunoglobulin production against human Namalwa cells caused by oxidized cholesterol

Article abstract of DOI:10.1271/bbb.60.1362

The effects of oxidized cholesterols on proliferation and IgM production of human lymphoblastoid Namalwa cells were examined. An oxidized cholesterol mixture, in contrast to cholesterol, was a potent cytotoxin to Namalwa cells. Among oxidized cholesterols examined, 25-hydroxycholesterol was the most cytotoxic. However, no oxidized cholesterol examined suppressed IgM production, although cholestanetriol and 7-ketocholesterol did suppress it. Thus, oxidized cholesterols are cytotoxic to lymphocytes, while the influence on the immunoglobulin production may be marginal.

Full text of DOI:10.1271/bbb.60.1362

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Bioscience, Biotechnology, and Biochemistry
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Cytotoxicity and Suppression of Immunoglobulin
Production against Human Namalwa Cells Caused by
Oxidized Cholesterol
Kyoichi Osadaa, Takehiro Kodamaa, Noritaka Matsuoa, Koji Yamadaa & Michihiro Suganoa
a Laboratory of Food Science, Kyushu University, School of Agriculture, Fukuoka 812-81,
Japan
Published online: 12 Jun 2014.
To cite this article: Kyoichi Osada, Takehiro Kodama, Noritaka Matsuo, Koji Yamada & Michihiro Sugano (1996)
Cytotoxicity and Suppression of Immunoglobulin Production against Human Namalwa Cells Caused by Oxidized Cholesterol,
Bioscience, Biotechnology, and Biochemistry, 60:8, 1362-1364, DOI: 10.1271/bbb.60.1362
To link to this article: http://dx.doi.org/10.1271/bbb.60.1362
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