Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols

Article abstract of DOI:10.1021/jm00207a014

A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for β-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12-15 were found to retain the β-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.