Stereoselective synthesis of 5-methylphosphono-D-arabino hydroximolactone, inhibitor of glucosamine-6-phosphate synthase and phosphoglucose isomerase

DOI: 10.1016/S0040-4039(97)10514-7

Source and publish data:

Tetrahedron Letters p. 287 - 288 (1998)

Update date:2022-08-03

Topics:

Authors:

Le Camus, Corentin

Chassagne, Alexia

Badet-Denisot, Marie-Ange

Badet, Bernard

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Article abstract of DOI:10.1016/S0040-4039(97)10514-7

Compound 2, synthesized from D-arabinose in 12 steps with an overall 4% yield, is a competitive inhibitor vs fructose-6P for both phosphoglucose isomerase and glucosamine-6P synthase.

Full text of DOI:10.1016/S0040-4039(97)10514-7

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Product name:methyl 2,3-di-O-benzyl-5-deoxy-5-diethylphosphonomethyl-α-D-arabinofuranoside

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