Bioorganic and Medicinal Chemistry Letters p. 3457 - 3460 (2004)
Update date:2022-08-02
Topics:
Hu, Baihua
Fan, Kristi Yi
Bridges, Kristie
Chopra, Rajiv
Lovering, Frank
Cole, Derek
Zhou, Ping
Ellingboe, John
Jin, Guixiang
Cowling, Rebecca
Bard, Jonathan
A new series of bis-statine based peptidomimetic inhibitors of human β-secretase (BACE 1) was developed by structure-based modification of the three regions to the initial lead 3: an N-terminus, a central bis-statine core, and a C-terminus. Introduction o
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