Direct synthesis of tricarbonyl(cyclopentadienyl)rhenium and tricarbonyl(cyclopentadienyl)technetium units from ferrocenyl moieties - Preparation of 17α-ethynylestradiol derivatives bearing a tricarbonyl(cyclopentadienyl)technetium group

Article abstract of DOI:10.1002/ejic.200300731

The preparation of new tricarbonyl(cyclopentadienyl)rhenium and tricarbonyl(cyclopentadienyl)technetium derivatives is described, The approach used was applied to a cold target model, 17α-ethynylestradiol substituted at the 17α position by a ketotricarbonyl(cyclopentadienyl)rhenium group. The novel organometallic reaction applied here, when extended to potential radiopharmaceuticals, consists of a cyclopentadienyl-ligand transfer between ketoferrocenes and fac-[^99mTc((H₂O)₃(CO) ₃]⁺ in a water/DMSO 1:1 mixture. This reaction lead to the synthesis of a new estradiol derivative, labeled with ^99mTc. The synthesis of another product was performed by using [⁹⁹TcCl ₃(CO)₃]^2- as the Tc precursor and its X-ray crystal structure was determined. In each case high yields were obtained. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.