Stereoselective Total Synthesis of the Antitumor Antibiotic (-)-Bactobolin

Article abstract of DOI:10.1021/jo00252a060

The first total synthesis of the biologically active microbial metabolite bactobolin (2) has been achieved.An efficient, stereoselective route to 2 in 16 steps from previously prepared α-keto lactone 3 is outlined.