Antiestrogen Basicity-Activity Relationships: A Comparison of the Estrogen Receptor Binding and Antiuterotrophic Potencies of Several Analogues of (Z)-1,2-Diphenyl-1-phenyl>-1-butene (Tamoxifen, Nolvadex) Having Altered Basicit

Article abstract of DOI:10.1021/jm00344a015

A series of N-substituted (Z)-1,2-diphenyl-1-<4-(2-aminoethoxy)phenyl>-1-butenes, analogues of the antiestrogen tamoxifen (Nolvadex), in which the side-chain basicity is varied over a wide range, has been prepared to probe the importance of basicity in ev