Methotrexate Analogues. 16. Importance of the Side-Chain Amide Carbonyl Group as a Structural Determinant of Biological Activity

Article abstract of DOI:10.1021/jm00354a013

N-<<<2,4-Diaminopteridin-6-yl)methyl>amino>benzyl>-L-glutamic acid ("deoxyaminopterin", 1), a new aminopterin analogue containing a CH2 group in the side chain in place of the amide C=O, was synthesized by condensation of 2,4-diamino-6-(bromomethyl)pterid