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2789
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44, 4783; (f) Kamal, A.; Sandbhor, M. Bioorg. Med.
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reduced pressure, and the resulting thick liquid purified
by silica gel column chromatography [eluent: methanol/
25
ethyl acetate (10:90)] to furnish the NPS-2143. ½aꢁD
¼
þ13.3 (c 1.2, CHCl3); IR: 3355, 2927, 2857, 2231,
9. Hoff, B. H.; Anthosen, T. Tetrahedron: Asymmetry 1999,
10, 1410.
1590, 1451, 1377, 1285, 1038, 781 cmꢀ1 1H NMR
;
(200 MHz, CDCl3): d 1.20 (6H, s), 2.90–3.20 (2H, m),
3.30 (2H, s), 4.1–4.2 (2H, m), 4.30–4.50 (2H, m), 6.85
(1H, d, J = 8.9 Hz), 6.90–7.0 (1H, d, J = 7.4 Hz), 7.20–
7.50 (5H, m), 7.60–7.80 (2H, m), 8.10–8.20 (1H, d,
J = 8.9 Hz); FAB+ (m/z): 409 (M++1); Anal. Calcd
for C24H26ClN2O2: C, 70.49; H, 6.16; N, 6.85. Found:
C, 70.38; H, 6.15; N, 6.74.
10. (a) Kamal, A.; Chouhan, G. Tetrahedron Lett. 2005, 46,
1489; (b) Kamal, A.; Chouhan, G. Tetrahedron Lett. 2005,
45, 8801; (c) Kamal, A.; Chouhan, G. Adv. Synth. Catal.
2004, 346, 579; (d) Kamal, A.; Chouhan, G. Tetrahedron
Lett. 2004, 13, 815.
11. For reviews see: (a) Holbrey, J. D.; Seddon, K. R. Clean.
Prod. Process 1999, 1, 223; (b) Welton, T. Chem. Rev.
1999, 99, 2071; (c) Wasserscheid, P.; Keim, W. Angew.
Chem., Int. Ed. 2000, 39, 3772; (d) Sheldon, R. Chem.
Commun. 2001, 2399; (e) Olivier-Bourbigou, H.; Magna,
L. J. Mol. Catal. A 2002, 182–183, 419; (f) Dupont, J.; de
Souza, R. F.; Suarez, P. A. Z. Chem. Rev. 2002, 102, 3667;
(g) Wasserscheid, P.; Welton, T. Ionic Liquids in Synthesis;
Wiley-VCH: Weinheim, 2003; (h) Ionic Liquids as Green
Solvents: Progress and Prospects; Rogers, R. D., Seddon,
K. R., Eds.; ACS Symposium Series 856; ACS: Washing-
ton, 2003.
Acknowledgement
We are thankful to the Department of Science and Tech-
nology, New Delhi, for the financial assistance of the
Grants-in-Aid project under SERC (No. SR/S1/OC-
36/2003). One of the authors G.C. is thankful to CSIR,
New Delhi, for the award of senior research fellowship.
12. (a) Park, S.; Kazlauskas, R. J. Curr. Opin. Biotechnol.
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