Journal of Medicinal Chemistry p. 376 - 380 (1984)
Update date:2022-08-02
Topics:
DeGraw
Christie
Brown
Kelly
Kisliuk
Gaumont
Sirotnak
The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox
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