Journal of Medicinal Chemistry p. 632 - 637 (1984)
Update date:2022-07-29
Topics:
Quick, James
Herlihy, Patricia
Howes, John F.
A method for preparing a variety of 7-alkyl-6,7-didehydromorphinans from the corresponding 6-morphinanones is described.The key intermediates in this sequence are the 7-formyl derivatives.The two epimeric B/C-trans-7-(1-hydroxypentyl)morphinans (16a, b) are stereochemically similar to the endo-ethanotetrahydrooripavines and are extremely potent in the mouse writhing test.The corresponding B/C-cis-7-(1-hydroxypentyl)morphinans are inactive in this test.
Tianjin Tensing Fine Chemical Research Develop Centre
Contact:86-022-23718576,13032267585
Address:2-2-201,13 Guiyuan road,Huayuan Industry district,Tianjin,china
LIANYUNGANG YC FINE CHEMICAL CO., LTD
Contact:+86-518-858 99188
Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
Contact:86-10-62983737; +86-10-51287608
Address:4/F Building C, 2 Shangdi Xinxi Road
Zhenjiang Haitong Chemical Industry Co., Ltd.
Contact:+86 (511) 8448-0369
Address:Baoyan Town, Dantu District, Zhenjiang City, Jiangsu, China
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Doi:10.1002/hlca.19830660731
(1983)Doi:10.1021/ic051733t
(2006)Doi:10.1002/jps.2600540909
(1965)Doi:10.1007/BF00515344
(1983)Doi:10.1021/jo01058a522
(1962)Doi:10.1016/j.jorganchem.2010.09.010
(2011)
