Journal of Medicinal Chemistry p. 632 - 637 (1984)
Update date:2022-07-29
Topics:
Quick, James
Herlihy, Patricia
Howes, John F.
A method for preparing a variety of 7-alkyl-6,7-didehydromorphinans from the corresponding 6-morphinanones is described.The key intermediates in this sequence are the 7-formyl derivatives.The two epimeric B/C-trans-7-(1-hydroxypentyl)morphinans (16a, b) are stereochemically similar to the endo-ethanotetrahydrooripavines and are extremely potent in the mouse writhing test.The corresponding B/C-cis-7-(1-hydroxypentyl)morphinans are inactive in this test.
Zhejiang Chemline International Co., Ltd.
Contact:+86-571-88062298
Address:Hengdian Industry Area, Dongyang, Zhejiang, China
Shandong Yubin Chemical CO.,LTD
website:http://www.yukaichem.com/en.html
Contact:+86-536-8865336
Address:binhai economic development zone，262737 shangdong，china
Hangzhou Donglou Bio-nutrient Co., Ltd.
Contact:+86-571-82225795,13967112289
Address:Louta Town, Xiaoshan,Hangzhou,Zhejiang
Contact:+86-533-3112891
Address:zibo
Doi:10.1002/hlca.19830660731
(1983)Doi:10.1021/ic051733t
(2006)Doi:10.1002/jps.2600540909
(1965)Doi:10.1007/BF00515344
(1983)Doi:10.1021/jo01058a522
(1962)Doi:10.1016/j.jorganchem.2010.09.010
(2011)
