Bioorganic and Medicinal Chemistry Letters p. 2899 - 2901 (2003)
Update date:2022-08-04
Topics:
Dunkley, Christopher S.
Thoman, Charles J.
A series of compounds containing an N-(4′-substituted-3′- nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4′-position of the phenyl sydnone framework. Out of the six novel compounds, the 4′-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.
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