Chemistry of Heterocyclic Compounds p. 210 - 215 (1984)
Update date:2022-08-02
Topics:
Bulychev, Yu. N.
Korbukh, I. A.
Preobrazhenskaya, M. N.
3-Cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine, fusion of which with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose gave its per-O-acetylated 1-β-D-ribofuranoside in 61percent yield, was synthesized from 3,4-dicyano-5-aminopyrazole.O-Deacetylation of the per-O-acetylated 1-β-D-ribofuranoside was carried out by the action of 1percent HCl in methanol. New pyrazolo<3,4-d>pyrimidines were obtained by the reaction of 3-cyano-4-methylmercaptopyrazolo<3,4-d>pyrimidine and its 1-riboside, as well as 3-cyano-4-aminopyrazolo<3,4-d>pyrimidine, with a number of nucleophilic reagents.The cytotoxic activities of the compounds obtained were studied.
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