
Chemistry of Heterocyclic Compounds p. 1354 - 1357 (1986)
Update date:2022-08-04
Topics:
Kuroyan, R. A.
Sarkisyan, V. V.
Vartanyan, S. A.
Bromination of 1-methylpiperidine-4-carboxaldehyde gave 4-bromo-1-methylpiperidine-4-carboxaldehyde hydrobromide which was used to synthesize 1,4,9-triazaspiro<5,5>undecane and 3,7,11-triazaspiro<5,6>dodecane.Cyanoethylation and alkylation with various alkyl halides gave their mono- and di-substituted derivatives.The side chain nitrile group was reduced and the hydrazide was obtained from the ester analog.
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