Tetrahedron p. 137 - 144 (1984)
Update date:2022-08-04
Topics: Synthesis Oligonucleotides Experimental Chemical Nucleotides Activating reagents
Letsinger, R. L.
Groody, E. P.
Lander, N.
Tanaka, T.
1,1-Dimethyl-2,2,2-trichloroethyl has merit as a protecting group for P-O in the phosphite-triester synthesis of oligonucleotides.Use of this group enables one to simplify procedures for preparing active nucleoside phosphorochloridite reagents, to remove
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(1954)
